O2 is one of actress Nayanthara's most anticipated films, in which she plays a single mother of a child who fights for his life every day. The youngster has a medical problem that prevents him from breathing without assistance. To keep alive, he requires regular oxygen support. A surgery could help the boy's medical condition. The youngster and his mother take a bus to Cochin's hospital to participate in the surgery. Their bus strikes with a big hole on the way to their destination. The rest of the story is about how they dealt with difficulties throughout the rescue attempt. O2, produced by Dream Warrior Pictures, will be released on Disney Plus Hotstar on June 17 in Tamil, Telugu, Kannada, and Malayalam.