What made Delta, Delta Plus variants of Covid more virulent

17-10-2021 Sun 14:46 IST | IANS | Health
What made Delta, Delta Plus variants of Covid more virulent

London, Oct 17:  The Delta and Delta Plus Covid-19 variants were less well neutralised by antibodies from infected and vaccinated individuals as compared to the original virus, making them more dangerous and contributing to its rapid global spread, according to a study.

The Delta variant (B.1.617.2) first emerged in India during 2020 and subsequently spread globally within a short time period.

In addition to Delta, Delta Plus sub-variants have been observed which carry additional mutations that may make them more dangerous.

In the study published in the journal 'Cell Reports', the researchers showed that both Delta and Delta Plus infect lung cells with higher efficiency than the original virus (the virus that circulated during the early phase of the pandemic).

The Delta Covid variant was found to be better at entering lung cells compared to the original virus and also at fusing infected lung cells with uninfected cells. This enabled the variant to spread widely and infect more people.

"It is conceivable that by fusing cells in the respiratory tract, the Delta variant may spread more efficiently and induce more damage. This could contribute to a more severe course of Covid-19," said Arora Prerna, Scientist at the German Primate Center -- Leibniz Institute for Primate Research in Gottingen, Germany.

Moreover, one of four antibodies (bamlanivimab) used to treat Covid-19 was not effective against Delta, and Delta Plus was even resistant against two therapeutic antibodies (bamlanivimab and etesevimab).

Similarly, antibodies generated upon vaccination with the BioNTech-Pfizer and Oxford-AstraZeneca vaccines were also less effective against Delta and Delta Plus compared to the original virus.

"Our results are consistent with the observation that vaccination efficiently protects against development of severe disease after infection with the Delta variant, but frequently fails to completely suppress infection. In light of the efficient protection against severe disease, the goal continues to be a high vaccination rate. This can prevent the healthcare system from being overwhelmed in case of increased spread of Delta and closely related viruses during the winter months, "said Stefan Pohlmann from the German Primate Center.


More News
Row as AIMIM member abstains from 'Vande Mataram' in Bihar Assembly
4 hours ago
KTR urges PM to declare Kaleshwaram or Palamuru national project
4 hours ago
Get rid of 'why should I care' attitude: Shah to IPS probationers
5 hours ago
Andhra CM Jagan assures all help to flood victims
5 hours ago
12 more fliers from 'at risk' countries test Covid positive in Hyd
5 hours ago
India's foreign exchange reserves down $2.71 bn
5 hours ago
Don't let off workplace sexual harassment accused on technical grounds: SC
5 hours ago
Vicky-Katrina wedding: Event-related stickers must on vehicles
5 hours ago
Mary Kom supports Special Olympics Bharat
6 hours ago
No curbs are planned on cinema theatres, says Telangana
6 hours ago
World Tour Finals: Already qualified for semis, Sindhu loses her final group match to Chochuwong
7 hours ago
Decisions on booster dose, jabs for kids on scientific advice: Mandaviya
8 hours ago
Windows 11 to make it easier to change default browsers
8 hours ago
IND vs NZ, 2nd Test: Agarwal's ton takes India to 221/4 at stumps on Day 1
8 hours ago
Andhra CM assures pay revision for employees in 10 days
9 hours ago
Omicron: NCBS monitoring situation in four top cities
9 hours ago
Global action needed to regulate technology like cryptocurrency: Sitharaman
9 hours ago
How strong is Cyclone Jawad? 'Gulaab se jyada, Titli se kam'
9 hours ago
Lockdown should be 'last resort' to curb Omicron: WHO
9 hours ago
Deep depression intensifies into cyclonic storm and heading for north Andhra Pradesh in Bay of Bengal
9 hours ago
Clashes with China: Indian warships were deployed at forward positions, says Navy Chief
10 hours ago
India can lead the digital society: Mukesh Ambani
10 hours ago
Google Search adds new tools to help find doctors
10 hours ago
Actor Siddharth: Stop persecuting the film industry
10 hours ago
Anti-Imran song shared from Pak embassy in Serbia's official account
10 hours ago
Contestants undergo tough tasks in 'Bigg Boss Telugu 5' to win 'Ticket To Finale'
11 hours ago
Centre clarifies on 3rd wave possibility after Omicron detection
11 hours ago
Prepare for Omicron surge, WHO warns Asia-Pacific nations
11 hours ago
Lookinh beyond 'Major', Telugu actor Adivi Sesh eyes Bollywood projects
11 hours ago
GSK's early data shows Covid antibody drug effective against Omicron
13 hours ago