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Don't blame genes for all diseases that run in families

Thu, Jul 21, 2016, 12:28 PM
Related image London, July 21: A family history of the disease may be as much the result of shared lifestyle and surroundings as inherited genes, a study says.

Factors that are common to the family environment - such as shared living space and common eating habits - can make a major contribution to a person's risk of disease, the study found.

The study, published in the journal Nature Genetics, used data from the UK Biobank that recruited 500,000 people aged between 40-69 years in 2006-2010 from across the country with the with the aim of improving the prevention, diagnosis, and treatment of a wide range of serious and life-threatening illnesses.

"The huge UK Biobank study allowed us to obtain very precise estimates of the role of genetics in these important diseases,” said Professor Chris Haley, Roslin Institute, the University of Edinburgh in Britain.

"It also identified those diseases where the shared family environment is important, such as heart disease, hypertension, and depression, and also equally interestingly those where the family environment is of limited or no apparent importance, such as dementia, stroke, and Parkinson's disease," Haley noted.

Previous studies have identified genes that are linked to numerous medical conditions, yet this only account for part of a person's likelihood of developing disease.

The new research looked at incidences of 12 common diseases including high blood pressure, heart disease, and several cancers and neurological diseases.

By not accounting for shared environmental factors, scientists may overestimate the importance of genetic variation by an average of 47 per cent, the study found.
Agency: IANS
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