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Why common BP pill fails in some patients

Tue, Apr 21, 2015, 01:33 PM
Washington, April 21, 2015: Thiazide *****, a common group of salt-lowering medicines used to treat high blood pressure for decades, can lower blood pressure for a while and then stop working in some patients. Researchers from University of Maryland's School of Medicine (UMSOM) have now revealed a key mechanism for this failure.

Paul Welling and his team found the specific genes and pathways used by the kidneys to compensate for thiazides' activity.

“This is the first time we really understand how this process works. It is as if the kidney knows that it's losing too much salt and activates mechanisms to retain salt in other ways,” explained Welling, an expert on potassium and sodium balance, kidney disease and hypertension.

Thiazides work by inhibiting the movement of salt through the kidney, causing the kidneys to expel salt and water.

Salt often raises blood pressure by increasing the amount of water in the vascular system; over time, this fluid puts pressure on the heart and blood vessels, and can cause hypertension.

The kidney counteracts the *****' effect by retaining more salt, keeping blood pressure high.

Welling and his collaborators studied an animal model that was genetically engineered to inhibit salt retention, mimicking the effect of thiazides.
Agency: IANS

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